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What is hypercholesterolemia?

Hypercholesterolemia is a condition in which the level of cholesterol in your blood is high. When you have too much cholesterol, deposits of fat in the blood called plaque form inside blood vessel walls. The blood vessel walls thicken and become narrower (a condition called atherosclerosis).

This change in the blood vessels reduces blood flow through the blood vessels, increasing your risk of heart disease and possibly leading to heart attacks or strokes.

Cholesterol is a naturally occurring fatty substance. Your body needs small amounts of cholesterol to make and maintain nerve cells and to produce hormones. Most of the cholesterol in your blood is made by your liver from the fats, carbohydrates, and proteins you eat. You also get cholesterol by eating animal products such as meat, eggs, and dairy products.

The two most important components of cholesterol measurements are LDL (low-density lipoprotein) and HDL (high-density lipoprotein). LDL and HDL carry cholesterol through your blood. LDLs carry a lot of cholesterol, leave behind fatty deposits on your artery walls, and contribute to heart disease. HDLs do the opposite. They clean the artery walls and remove extra cholesterol from the body, thus lowering the risk of heart disease. LDL is called "bad" cholesterol. (You can think of "L" for "lousy" cholesterol.) HDL is called "good" cholesterol (think of "H" for "healthy" cholesterol). It is good to have low levels of LDL and high levels of HDL.

How does high cholesterol occur?

The main cause of high cholesterol is eating foods that are high in saturated fat or cholesterol. Other possible causes are:

- an inherited problem with the way your body processes cholesterol

- a disease that raises the cholesterol level (for example, diabetes, kidney disease, liver disease, or hypothyroidism).

What are the symptoms?

High cholesterol is a silent disease. There are no symptoms until problems have already developed, such as the chest pain of a heart attack or calf pain with walking, caused by narrowed or blocked arteries to the legs.

How is it diagnosed?

Your health care provider may give you a physical exam.

Your provider may ask about your diet, exercise, smoking habits, and diseases and health problems in your family.

You will have blood tests to check your cholesterol level.

These lab tests usually measure your total cholesterol level as well as the levels of HDL, LDL, and triglycerides.

When you get your cholesterol checked, your provider will give you a number for your total cholesterol level. A total cholesterol less than 200 is good, 200 to 239 is borderline high, and 240 or above is high.

HDL levels of 60 mg/dL or more help to lower your risk for heart disease. An HDL less than 40 mg/dL is a major risk factor for heart disease.

Your provider will determine if you have other risk factors for heart disease to determine if your overall risk is low, moderate, or high. This will help you know what your LDL goal should be.

- If you have a low risk of heart disease, the recommended level of LDL is less than 160.

- If you have a moderate risk for heart disease, your goal is less than 130.

- If you have heart disease, diabetes, or a high risk of heart disease, your LDL should be below 100.

How is it treated?

The goal of most cholesterol treatment is to decrease the LDL in your blood and to raise the HDL. For every 1% decrease in cholesterol level, your risk of heart disease is reduced 2%.

A diet high in fiber and low in total fat, saturated fat, and cholesterol can help to lower cholesterol levels.

For more information on changes you can make in your diet, see Health Maintenance: Controlling Cholesterol.

You will need to lose weight if you are overweight. You should also exercise as recommended by your health care provider.

If diet and exercise are not enough to reduce your cholesterol level, your health care provider may prescribe medicine. Statins are a class of drugs that lower blood cholesterol. Statins that are commonly used are atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin. Other drugs used to lower blood cholesterol include cholestyramine, niacin, and gemfibrozil. Each medicine has slightly different effects. Your provider will choose the best medicines for you. In some cases more than 1 medicine may be prescribed.

How can I take care of myself and prevent high cholesterol?

In addition to changing your diet, you can help lower your cholesterol by the following:

- Get more exercise, especially aerobic exercise. Ask your health care provider about an exercise prescription. Start slowly to avoid injury. Exercise helps raise HDL levels, improve circulation, decrease body fat, and tone muscles.

- Don't smoke. Smoking lowers your HDL.

- Maintain a normal weight.

- Have your cholesterol levels and weight checked by your health care provider.

Developed by McKesson Provider Technologies.

Published by McKesson Provider Technologies.

Copyright © 2005 McKesson Corporation and/or one of its subsidiaries. All Rights Reserved.

This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.